.Now researchers at Stanford University believe they may have hit on a reason why a having a coffee or tea break is so good for us.Inflammation also plays a key role in many other diseases, the research study said.What weve shown is a correlation between caffeine consumption and longevity. And weve shown more rigorously, in laboratory tests, a very plausible mechanism for why this might be so.The study was published in Nature Medicine.The authors found that in an ongoing study following participants aged 20-30, and another group of people aged 60, those who tended to drink more caffeinated beverages had lower levels of inflammatory compounds in their blood.

It helps to block chemicals in the blood that promote inflammation, they say. Tests on the blood of people fewer of the chemicals linked to inflammation - were found to have more caffeine in their bloodstream.Further investigation revealed that they, as might be expected, drank more coffee than their peers.Caffeine, the ingredient that gives coffee, tea and some fizzy drinks a lift blocks chemicals in our blood that promote inflammation. Many studies have shown this association. A chemical found in chocolate, theobromine, was also found to have an anti-inflammatory effect, although not as pronounced as caffeine. Drinking coffee and tea may help people to live longer by reducing chemicals in the blood that can trigger heart disease, researchers have found.US scientists believe theyve found the answer - and its to do with caffeine.David Furman of the Stanford Universitys Institute for Immunity, Transplantaion and Infection said: More than 90 per cent of all noncommunicable diseases of aging are associated with chronic inflammation. It also found more platelets platelets, which make blood more likely to clot. The key chemical combated by caffeine is called Interleukin-1-beta.London: Why do coffee drinkers tend to have a longer life? The finding that coffee drinkers tend to live longer than people who abstain has long puzzled scientists. Inflamed blood vessels are more likely to become stiffer - a risk factor for heart disease.Dr Furmann added: Its also well known that caffeine intake is associated with longevity. China Insulin assembly machine for sale It also led to immune cells - white blood cells that fight infection and - clogging the animals kidneys.

When injected into mice, IL-1-Beta led to massive systemic inflammation, along with high blood pressure.His colleague Mark Davis added: Our findings show that an underlying inflammatory process, which is associated with aging, is not only driving cardiovascular disease but is, in turn, driven by molecular events that we may be able to target and combat. Weve found a possible reason for why this may be so.Further tests in the laboratory in human cell cultures found that caffeine had an active role in combating the chemicals that trigger inflammation.Dr Davis said: That something many people drink - and actually like to drink - might have a direct benefit came as a surprise to us.

New advances are allowing researchers to study cancer via the bloodstream where tumor cells shed small, detectable pieces of their DNA, according to researchers.Although tumor biopsies are generally used to assess changes in a cancer's DNA, blood samples can do the same thing, according to the study presented at the annual meeting of the American Society of Clinical Oncology.And because genetic changes in cancer DNA occur even before tumor growth becomes evident in a scan, blood samples can help health professionals adjust a patient's treatment sooner. Chicago, United States: Blood samples can be just as effective as invasive tissue biopsies in monitoring cancer and can help doctors better prescribe treatment, a study revealed on Saturday.."

These findings suggest that analysis of shed tumor DNA in patient blood, also known as a liquid biopsy, can be a highly informative, minimally-invasive alternative when a tissue China Vaccine needle assembly machine for sale biopsy is insufficient for genotyping or cannot be obtained safely," said study presenter Philip Mack, professor and director of molecular pharmacology at the University of California Davis Comprehensive Cancer Center.The study was carried out using blood samples from more than 15,000 patients and 50 types of tumors.Blood tests can also provide a more comprehensive sample of a tumor's DNA since biopsy tissue comes from only one part of a tumor and therefore may not provide a sample of the changing DNA."Having a good, reliable option beyond a tumor biopsy could have a major impact on our ability to select the right therapy for the right patient," said Sumanta Kumar Pal, a medical oncologist at the City of Hope cancer center in California, who was not involved in the research.By assessing this DNA doctors can "monitor changes in the cancer as it evolves over time, which can be critical when patients and physicians are discussing treatment options for continued tumor control," according to a preview of the study.Researchers used a test by California-based Guardant Health, which looks for mutations in 70 cancer-related genes."

The fact that genomic mutations vary not only patient to patient but also change over time has been a constant challenge in cancer treatment, especially in the precision medicine era" he said.And blood samples allow doctors to do so without resorting to an involved, surgical tumor biopsy, said researchers on the study, one of the largest ever conducted on cancer genomics.The study was carried out using blood samples from more than 15,000 patients and 50 types of tumors.

One limitation of the research is that participants weren’t given specific foods to consume and diets were assessed based on self-reported surveys asking people at several points to recall what they ate in the previous 24 hours, the authors acknowledge. Participants ranged in age from 25 to 75. Blood vessel dysfunction and high LDL cholesterol are both risk factors for type 2 diabetes, which is associated with obesity and aging and occurs when the body can’t make or process enough of the hormone insulin. Katz of the Yale University Prevention Research Center in Derby, Connecticut.". Results from the periodic diet surveys aren’t enough to prove walnuts caused the changes in LDL cholesterol or blood vessel function, Holt added by email. The California Walnut Commission funded the study and has compensated Katz for speaking engagements. "Walnuts and other tree nuts are a healthful source of plant-based protein and fat," Tobias, who wasn’t involved in the study, said by email.

When people in the study added 56 grams of walnuts (2 ounces, or about 14 walnuts) to their daily diet for six months, they had improvements in blood vessel function and reductions in "bad" LDL cholesterol, which builds up in blood vessels and can lead to blood clots and heart attacks. David L. Even so, there is plenty of previous research linking consumption of walnuts to improved markers of heart health and lower risks of diabetes and heart disease, noted Deirdre Tobias, an epidemiologist at Brigham and Women’s Hospital and Harvard Medical School in Boston. All had multiple risk factors for diabetes, such as being overweight, or having high blood sugar, blood pressure or cholesterol, or having excess fat around the midsection. After China safety Vaccine syringe for sale a three-month break from the experiment, researchers then switched the groups and assigned walnuts to the participants who were previously asked to abstain from eating them. The study also wasn’t designed to show whether walnuts could prevent diabetes, which makes the results less reliable. Within these groups, half of the participants were assigned at random to add walnuts to their diet for six months. "Adding walnuts to your diet will improve your diet quality and health – cardiometabolic health specifically – and you can add walnuts without fear of weight gain because they are very satiating and appear to bump out other calories quite reliably and make room for themselves," said study author Dr. For the study, the researchers randomly assigned 31 men and 81 women at high risk for diabetes to follow a reduced calorie diet with or without nutrition counseling. study suggests. "They are a food that (is) consistent with overall dietary recommendations and can easily be incorporated into a patient’s diet, if they like walnuts and are not allergic. After taking into account factors such as age, exercise habits, calorie consumption and fatty acid intake, the study found walnuts were linked to improved diet quality regardless of whether people received nutrition counseling.

The nuts didn’t seem to improve high blood pressure and high blood sugar, two other risk factors for diabetes, Katz and colleagues reported in BMJ Open Diabetes Research and Care. Even though the data from the study suggest that adding walnuts to the diet can help maintain overall healthy eating habits, more research from larger and longer-term studies is still needed to fully understand the potential benefits of walnuts, said Roberta Holt, a nutrition researcher at the University of California, Davis, who wasn’t involved in the study. Walnuts, which are rich in fatty acids and other nutrients like folate and vitamin E, weren’t linked to weight gain in the study even though they are a high-calorie food.Walnuts are rich in fatty acids and other nutrients like folate and vitamin EEating a handful of walnuts each day might help keep the doctor away, at least for some people who are at risk of developing diabetes, a U. "While the intake of walnuts improved LDL cholesterol and vascular function from baseline, the control (no walnuts) also improved," Holt noted.

This idea was reinforced when the British started ruling us. At least the fashion industry seems to have started embracing the diversity of skin tones in our country. For a very long time, we have been embarrassed about this, owing to all the impositions we have had on us. "Many supermodels in the fashion industry are dusky and top models on the runway today are mostly beautiful olive-skinned girls. And thus, people started thinking that those who are fair live in the lap of luxury. Case in point is the recent Tanishq ad, which features a collection of South India-inspired jewellery donned by dusky models. They think they’re being trendy but don’t realise how shameful their attitude is," he says.This colour bias can be seen in every sphere of Indian life, right from our movies to even matrimonial columns — notorious for seeking ‘fair’ women.Resonating the same idea, designer Rahul Mishra feels today’s youth cannot be fooled by  ‘fair is beautiful’ propaganda.

The ad has captured the attention of many!While light-complexioned models have ruled the ramps for decades, many A-list fashion designers like Sabyasachi Mukherji, Anju Modi, Rahul Mishra and others have been working with dusky models and making them the face of their collections. Though both of them were dark. But if you look at ancient Indians, we have two very strong examples of Lord Ram and Lord Krishna.Giving an insight into how Indians started perceiving fairness to be a synonym of beauty, Rahul shares, "This notion that only fair or light-complexioned people are beautiful is a pretty recent development — most probably after the Turks and Persians came to India for trade and later invaded the land and ruled over it. Ad guru Prahlad Kakkar feels the marketing and advertising industry will only change when it sees society changing. But things have slowly been changing..Fashion designer Anju Modi’s collectionFashion guru Prasad Bidapa welcomes this move and says that brands need to be more accepting of the Indian skin tone."A model walking the ramp in designer Rahul Mishra’s collectionToday, the colour bias seems to be reinforced by advertisements that continuously equate fair skin with not just beauty, but also happiness. However, brands in India try to pretend they’re foreign by using white models, and I don’t know who they think they’re fooling."While the ’90s saw dusky supermodels including the likes of Noyonika Chatterjee, Carol Gracias and Mehr Jesia, many brands have wanted only the fair-skinned girls on their billboards until recently.In a country that insists that being fair is lovely, dark-skinned people have it tough."The last few years have seen a lot of changes in the China Infusion set for sale way Indian society perceives beauty. "There have been many dusky models and even leading heroines in the industry. But society is opening up now and advertisers today are trying to reinvent themselves.

It just reveals their shallow mindsets. "Yes, there are fair Indians but we are dusky people, mostly. So obsessed are we with fair skin that we forget that a majority of our people are dusky or dark-skinned. Internationally too, there are many dusky and dark-skinned girls who are making a mark in the fashion industry," says Rahul. I personally never went just after the light-complexioned models, male or fe male," says Anju Modi. We have become open and are starting to move away from the idea that for a girl to be beautiful, she has to be fair.

His art-dealer father, China Infusion set for sale Hildebrand, amassed it after being enlisted by the Nazis to sell so-called "degenerate" modern art they had seized from German museums. The Bern museum is now working with the German Lost Art Foundation, which tracks Nazi era art thefts, to unravel the collections murky past, though not everyone is pleased with the progress. It accepted, on the condition works whose lineage was unclear must remain in Germany.Bern Museum of Fine Arts head Nina Zimmer, who took ownership of 150 drawings, lithographs and paintings this week ahead of an exhibition slated to begin in November, said research shows none of these were stolen by National Socialists.A Swiss museum director preparing for a Nazi-era art collections long-awaited public unveiling later this year said Friday that her goal remains finding heirs to any works that may have been looted from Jewish owners. "One of the biggest challenges is reaching reliable conclusions and addressing research gaps, especially in such a short period of time," the foundations Nadine Bahrmann said in an email.Christopher Marinello, a lawyer who helped Rosenbergs heirs recover their lost Matisse in 2015, said the pace of research has been glacial -- even after he provided German researchers with "full and complete provenance on a silver platter," he said.."Every restitution is a victory for us," Zimmer said in an interview, while acknowledging such provenance sleuthing remains unpredictable.

When Cornelius Gurlitt died aged 81 in 2014, he named the Bern museum as benefactor."   The German Lost Art Foundation, which took over from a previous task force last year, contends it is making "positive strides" including digitizing documents and making them available via the countrys Federal Archives. "It is the most important cache of art from the Nazi era to be found in private hands since the immediate postwar period," said Jonathan Petropoulos, a Claremont McKenna College history professor in California. But questions linger over the provenance of some of the collections pieces still in Germany, where a 2012 raid by authorities on a Munich apartment produced a sensation: 1,500 long-lost works by modern masters, including Pablo Picasso, Otto Dix and Henri Matisse. "There is an inherent lack of sympathy for the victims of Nazi looting.MASSIVE TROVEBefore its discovery five years ago, the massive trove was hidden for years in the German and Austrian homes of Cornelius Gurlitt. "I cannot make any promises.The foundation is now scrutinizing 1,039 works from Gurlitts collection, it said, of which 152 have produced some provenance evidence or claims from possible heirs that indicate they could be Nazi loot."

In addition to Zimmers exhibition in Bern, the Bundeskunsthalle in Bonn, Germany, is also planning to display items from the collection, which to date has produced only five works confirmed to have been stolen by the Nazis.Four have been returned to heirs, so far, including a Matisse portrait, "Sitting Woman," that belonged to Paris-based collector Paul Rosenberg.Though original estimates for the collections value topping billion were likely exaggerated, experts said, the find is still spectacular.GOVERNMENT BUREAUCRACY"Internal and governmental bureaucracy in Germany is quite out of control," Marinello said in an email on Friday. Its work continues until December.

However, toll activists have alleged that the MSRDC is delaying the process of bringing in transparency and shielding the contractors who are under-reporting the traffic data. The MSRDC is going to develop a software with the help of "Wide Area Network" (WAN) connectivity, and all WAN servers are to be connected with the main server at the MSRDC’s head office in Mumbai, which will not allow the contractors to under-report the traffic data.. After the MSRDC in July 2015 had found under-reporting in the toll collection it had claimed to bring transparency by having real time toll collection system.Toll activists claim this is just another time-consuming tactic and for developing the software the MSRDC should go by the bidding process as prescribed by the state government norms. The MSRDC has no expertise on developing softwares and by taking things the other way it is just delaying the process of bringing in transparency," said RTI and toll activist Sanjay Shirodkar. "

The process of developing software is not going to be transparent as there will be no bidding for the same. Further, the MSRDC last month scrapped the bids for real time toll collection for the monitoring purpose at five entry points of the city and the Mumbai-Pune Expressway (MPE) citing conflict of interest between the company that was short-listed as the lowest bidder and the company that collects tolls on the expressway.

After inviting bids and scrapping the same for real time toll collection, the Maharashtra State Road Development Corporation (MSRDC) has now taken a U-turn claiming that the corporation will not appoint third party contractors for developing a software for real time toll collection and instead will self appoint staff to initiate the process of real time toll monitoring. "After scrapping bids for the real time toll collection we have now decided to appoint staff in the MSRDC itself for having the software being developed Infusion set packaging machine for sale for the real time toll collection," said, Radheshyam Mopalwar, managing director, MSRDC.

Designer K*** Uttam Ghosh’s V-Day collection comprises long, pleated one-piece red dress with antique zari neck details, paired with a grey jacket. She says, "My collection will appeal to those who do not like to go overboard with jazzy clothes. There are tunics studded with pearls and stones, zari kurtas, silk dresses and embellished suits. Also, there is a rust georgette angarkha with antique gold embroidery.What else would be the right occasion to be your stylish best then the Valentine’s Day And fashion designers are wooing love-struck divas with their special V-Day collections. The collection comprise deep red dresses, stoles and shirts and convey the bold and daring attitude," she says. Wearing what you love is certainly a confidence booster," says the designer, who has added dashes of purple and brown to her garments. "I have primarily designed for those who don’t feel comfortable in Western outfits." Fashion designer Poonam Bajaj of Citrine has used flowy fabrics like georgette, silk or zari for her V-Day collection. "My collection is for the bold youth of today, who are daring enough to experiment with interesting prints, colours and styles. Along with short and long dresses, she has created interesting ethnic options including salwaar kameez with dupatta.

These designs blur the line between masculinity and femininity and occasionally play with the boundaries of androgyny. "We have designed long gowns and dresses for the evenings as many people prefer to turn up in formal wear for parties. "These pieces can be teamed up with churidaars, leggings and even with denims," she Infusion set assembly machine for sale says.Anuradha Ramam’s V-Day collection highlights ethnic crafts and prints. This trend is inspired by the West," she adds. While some have diversified in terms of colour code and cuts, others have given interesting twists to conventional pinks and haute reds. Designer Shivali Misra Seth of Purple Paperbag has moved from the traditional colour code in her collection "Bold & Beautiful".

 Holly Gooding, a researcher at Harvard Medical School in Boston who wasn’t involved in the study.Among the young adults in the current study, higher BMIs were associated with an increased risk of high blood pressure, researchers report in Circulation.9 is overweight, 30 or above is obese and 40 or higher is morbidly or extremely obese. Centers for Disease Control and Prevention has a free online BMI calculator here: bit."No matter what they weigh, young people can still take steps to minimize their risk of heart attacks and other cardiovascular problems, Gooding added. The results also suggest that a higher BMI causes so-called left ventricular mass index to be higher, reflecting enlargement of the left ventricle in the heart, which pumps blood around the body, she said.Most previous research on the relationship between body mass index (BMI) - a measure of weight adjusted for height - and cardiovascular events like heart attacks has focused on older adultsResearchers looked the relationship between BMI and routinely collected cardiovascular data, such as blood pressure and heart rate, in more than 3000 17-year-olds born in the 1990s. Diastolic pressure indicates the pressure when the heart rests between beats. (The U.The study wasn’t a true controlled experiment designed to prove whether or how excess weight Injection needle assembly machine for sale might directly cause heart problems.9 is considered healthy, 25 to 29. "Our results support efforts to reduce BMI to within a normal, healthy range from a young age to prevent later cardiovascular disease. "Whether this is due to the increased metabolic demands of their higher weight, or increased inflammation generated by the fat cells themselves, or something else is unclear, as these mechanisms weren’t addressed in this study," Gooding said by email."

They also examined cardiovascular scans from 400 21-year-olds who were at higher genetic risk for an unhealthy BMI. "What we do know is that it is not simply due to lower physical activity or less optimal dietary patterns in these individuals, as these lifestyle factors were not associated with the genes for BMI. Systolic pressure reflects the pressure blood exerts against artery walls when the heart beats."A BMI of 18.)In the current study, the 17-year-olds with weight data available had an average BMI of about 23, in the healthy range, and average blood pressure readings of about 119 mmHG over 64 mmHG, also within a healthy range.

Even in early adulthood, being overweight is associated with an increased risk of high blood pressure and heart muscle damage that may set the stage for cardiovascular diseases later in life, a UK study suggests.The American Heart Association defines hypertension, or high blood pressure, as a systolic reading of 130 mmHg or higher and diastolic readings of 80 mmHg or higher.ly/2ylWKJC. "These findings suggest that BMI is likely to have an adverse causal impact on cardiac structure even in young adults," Wade said by email.5 to 24. "Everyone can protect their heart by staying physically active, eating a diet rich in fruits and vegetables and whole grains and low in sodium and added sugars, and avoiding smoking," Gooding said.

It is hoped that the findings could help fine-tune treatment for cancer patients and revitalise an interest in the use of microtubule-targeting agents (MTAs) which are commonly used as chemotherapies in cancer patients..Washington: A group of scientists has worked to develop a new technique in order to fine-tune cancer treatment.""This is really important because MTAs are already in clinic and commonly used as chemotherapies such as paclitaxel in cancer patients.Dr Robinson said, "This protein, Beta3-integrin, has been the focus of drug design over the last two decades because its expression is vastly increased in endothelial cells during blood vessel recruitment to tumours.The study appears in the journal EMBO Reports. Microtubules are protein structures in cells that help them move and divide."

The research team has long looked at Beta3-integrin as a better anti-angiogenic target because the protein is not expressed in normal blood vessels, but is expressed in tumour blood vessels. Targeting angiogenesis is therefore seen as crucial in many anti-cancer strategies", continued Robinson. This reduced the potential for unwanted side effects."Anti-angiogenic drugs stop tumours from growing their own blood vessels, and this, in turn, can slow the growth of cancer, or shrink it. The study revealed that tumour growth is better-reduced in mice when the expression of a particular protein called Beta3-integrin is targeted in combination with drugs that are already used in cancer patients. We found that targeting the protein Beta3-integrin in combination with the use of microtubule-targeting agents (MTAs) could be a good way to stop tumours recruiting a blood supply to grow. Meanwhile, Beta3-integrin inhibitors have been at the centre of cancer drug design for over 20 years and are well-tolerated in clinical trials", Robinson elaborated. "

However many anti-angiogenetic therapies target proteins that help the functioning of a patients normal blood supply - and this can lead to nasty side effects including haemorrhage, strokes, high blood pressure, and fatigue.Now the team has shown that targeting Beta3-integrin in combination with microtubule-targeting agents, which are widely used in cancer patients, works better than targeting Beta3-integrin alone.Specifically, the Robinson lab looked at how Beta3-integrin and microtubules interact with one another in the cells that line blood vessels (endothelial cells), and showed that microtubules behave differently when Beta3-integrin levels are reduced; the microtubules become more sensitive to the chemotherapies that are used to hit them.Lead researcher Stephen Robinson said, "Tumours must recruit their own blood supply to grow beyond a very small size and this process is called angiogenesis".According to a study conducted by the University of East Anglia, cancer therapies that cut off blood supply to a tumour could be more effective in combination with Safety injection needle for sale existing chemotherapeutic drugs.

One limitation of the study is that researchers only had blood pressure measurements from a single visit at each point in time, making it possible that some patients may have been misclassified. In the general U.Exposure to chemotherapy or radiation didn’t appear to influence whether cancer survivors developed high blood pressure. As a growing number of childhood cancer patients survive well into adulthood, more of them are living long enough to develop hypertension and other chronic health problems that often come with age.The current analysis involved 3,016 adults who were part of the St.High blood pressure, or hypertension, can be a particular problem for childhood cancer survivors because many of them have heart damage as a result of chemotherapy and radiation treatments.

Research has also tied some radiation therapy to cardiac rhythm disorders and structural damage in arteries and valves.S. By comparison, the general prevalence of hypertension among 18-to-39-year-olds in the U. Louis who wasn’t involved in the study. Deaths from cardiovascular disease are eight times more likely in childhood cancer survivors than in people without a history of tumors early in life. By age 30, 13 percent of them had high blood pressure, the study found."It is notable that survivors in our study had a higher-than-expected prevalence of hypertension regardless of their specific childhood cancer diagnosis or treatment," said lead study author Todd Gibson of St. Even when they do get diagnosed with high blood pressure, more than one in five of these patients don’t take medication or make lifestyle changes necessary to treat it, the study also found. "A cancer survivor needs to consider this issue early in adulthood because their rate of hypertension is very high and starts at a very early age. is about 7 percent, according to the Centers for Disease Control and Prevention (CDC). Serious events like heart attacks are five times more likely among cancer survivors than among their siblings who never had malignancies. Jude Lifetime Cohort Study. Some patients get anxious and develop temporary high blood pressure during checkups.It’s also possible that the findings might not apply to other cancer survivors because the participants received frequent follow-up care that not all survivors might get, the researchers point out.Cardiovascular disease is Wholesale Vaccine needle assembly machine Factory the second most common cause of death and serious illness for these cancer survivors, second only to malignancies, researchers note in Cancer Epidemiology, Biomarkers and Prevention. "

A young adult in their 30s or 40s does not think about screening for hypertension very often," Lenihan said by email. study suggests. population, according to the CDC, only about 30 percent of people ages 40 to 60 have hypertension. All had been treated for cancer as kids and survived at least 10 years. "The good news is that, unlike prior cancer therapy, high blood pressure is a modifiable risk factor," Gibson said by email.". Jude Children’s Research Hospital in Memphis, Tennessee.More than one in 12 adult survivors of childhood cancers may have undiagnosed high blood pressure, a U.S. Certain groups were most likely to have hypertension: men; non-Hispanic blacks, older survivors, and those who were overweight or obese, the study found. Daniel Lenihan, a researcher at Washington University in St.Previous research has linked cancer drugs known as anthracyclines to weakening of the heart muscle.